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Determining the mechanism of action (MOA) of novel or Obviously developing compounds typically relies on assays tailor-made for specific target proteins. In this article we explore an alternative strategy determined by pattern matching reaction profiles received applying cultured neuronal networks. Conolidine and cannabidiol are plant-derivatives w
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Electrode voltage signals had been superior-go filtered at 300 Hz following which spikes were detected with custom Matlab scripts based upon precision timing spike detection19 with spikes remaining detected if the height amplitude was higher than six times the normal deviation of noise. Sounds concentrations were calculated in 20 s blocks.It ab
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